This dual mechanism of action of docetaxel was found to be independent of p53 activity. The present data will help to understand the molecular mechanisms of action of docetaxel, ...

The second proposed mechanism of action for docetaxel lies in the inhibition of BCL2. The BCL2 gene family codes for a class of proteins that play important roles in the regulation of apoptosis.

Pertuzumab, an anti-HER2 humanized monoclonal antibody that inhibits receptor dimerization, has a mechanism of action that is complementary to that of trastuzumab, and combination therapy with the ...

The dual carboplatin-docetaxel resistant cell line will facilitate further investigation into mechanisms underlying the development of dual drug resistance in ovarian cancer." RELATED TOPICS ...

“This triple combination study is bringing us one step closer to helping with this unmet medical need. Plinabulin’s unique, immune-enhancing mechanism of action has a proven anti-cancer benefit that ...

Study: Pyrotinib versus placebo in combination with trastuzumab and docetaxel as first line treatment in patients with HER2 positive metastatic breast cancer (PHILA): randomised, double blind ...

NEW YORK (Sept. 17, 2012) -- The power of taxane-based chemotherapy drugs are misunderstood and potentially underestimated, according to researchers at Weill Cornell Medical College in the ...

Plinabulin (Plin), a small molecule with anti-cancer activity and a novel mechanism of action (MoA) in docetaxel (Tax)-induced neutropenia: Phase (φ) 2 results from a head-to-head comparison with ...

This arm was compared with 80 mg/m 2 paclitaxel weekly for 12 weeks, 100 mg/m 2 docetaxel every 3 weeks for four cycles, or 35 mg/m 2 docetaxel weekly for 12 weeks.

Evidence of Neutrophil Demargination and Bone Marrow Transit Time Reduction by Plinabulin Presented at Joint Meeting of the Society for Leukocyte Biology and International Endotoxin and Innate ...

Dec. 4, 2003 (San Antonio) — Docetaxel (Taxotere) produced better overall survival and longer time to progression than paclitaxel (Taxol) in a randomized head-to-head trial of the two taxanes ...