Accelerated storage conditions may be simulated followed by DSC of samples to detect drug recrystallization after extrusion as amorphous drug.

The advanced DSC technologies allow accurate characterization of a wide range of amorphous and crystalline ... of polymorphic forms of a substance Study of solid-state kinetics such as accelerated ...

Scientists at EPFL and AstraZeneca have developed a method to map the atomic-level structure of amorphous drugs, demonstrated on a GLP-1 receptor agonist candidate for diabetes and obesity treatment.

In this work, TASC was used in direct comparison to DSC to investigate changes ... Wiliams, R. O. (2015) Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery ...

The crystallinity of the drug was decreased, which indicated a more amorphous nature of the drug in XRD and DSC studies. Compared to pure drug dispersion, the optimized formulation exhibited a 3. ...

Polymorphism in pharmaceutical solids is the ability of a substance to exist ... was caused by heating the amorphous phase. These events are observed to be two exothermic transitions followed by a ...

As this instability has a potentially negative impact on storage and drug potency ... near infrared and modulated DSC. However, there are few techniques that can quantify amorphous contents below 1%.

This creates an amorphous, glass-like substance after shearing. As a result, conventional isobaric (constant pressure) cooling methods cannot achieve MDA densities—but shear processes like ball ...