Scientists have successfully described a crucial structure involved in DNA replication, placing another piece in the puzzle of how life propagates. Scientists at Van Andel Research Institute and ...

Given its importance, DNA replication is tightly regulated, primarily upon initiation at genomic sites known as origins of replication. A two-pronged structure known as a replication fork forms at ...

to show that RAD52 proteins form an unexpected spool-like structure composed of two rings of RAD52, each containing 11 copies of protein, that engages all three arms of the "DNA replication fork ...

the 'wings' and N-termini of RTP do not form intimate contacts with the DNA. This structure provides insight into the molecular basis of polar replication fork arrest based on a model of ...

Double ring structure protects DNA Spies and Pichierri had previously discovered that RAD52 is important in protecting stalled DNA replication forks. Their work suggested that this new function of ...

However, the process of DNA replication intrinsically disrupts nucleosomes ahead of the fork raising the question how chromatin structure is maintained across generations. Nucleosomes are re-assembled ...

The replication fork continues for a total of two-thirds of the genome before encountering the O L. This results in the single-stranded DNA in this region to form a stem-loop structure which ...

Furthermore, some features of DNA replication observed in mouse ES cells are shared with human iPS cells, suggesting that the slow replication fork with high origin density may be a hallmark of ...