Researchers at the Max Planck Institute for Evolutionary Anthropology have addressed a longstanding challenge in CRISPR ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

In the largest clinical genomic profiling study of non-Hispanic Black men with metastatic prostate cancer to date, ...

After editing, cells naturally repair the broken DNA in different ways. By visualizing thousands of DNA sequences from this process, KMAP revealed four common patterns of how the DNA was repaired ...

They found unusual patterns of indel mutations in cancers with faulty DNA repair mechanisms, known as post-replicative repair dysfunction (PRRd). This data allowed the researchers to develop the ...

DNA repair is crucial for human well-being ... They plan to automate searches for unusual patterns that signal hidden problems. Some teams explore how to cut off cancer cells from vital repair options ...

A study, which was published in the journal Occupational & Environmental Medicine, found that melatonin seems to help actually some people repair DNA damage while sleeping. As you may know ...

By analyzing shared mutation patterns among cells, they reconstructed these family ... “We have identified forms of DNA damage that manage to escape our DNA repair mechanisms and persist in the genome ...

They carry genetic instructions from DNA to ribosomes - the factories inside cells that ... The graphs highlighted major differences in repair patterns, depending on the DSB position. This ...

DNA and single-strand break repair proteins XRCC1, LigIII, Polβ, and FUS partition in PARP1 condensates, although in different patterns. While Polβ and FUS are both homogeneously mixed within PARP1 ...

Transcription-coupled repair (TCR) works to remove damage from ... activity of TCR shapes the distribution of mutations following DNA damage. Here, we examine strand-phased mutational patterns as a ...