In a study recently published in the journal Nature Chemical Biology, researchers reveal that two reactive byproducts of sugar metabolism—methylglyoxal and its metabolite lactoylglutathione ...

The Experimental Drug Development Center (EDDC), Singapore's national platform for drug discovery and development, has announced the presentation of updated clinical data for the ongoing Phase I ...

When scientists genetically engineered mice so that they could not generate an amino acid called cysteine, and then fed the mice a diet without any cysteine in it, the mice lost 30% of their body ...

First-in-human study of JSKN016, a bispecific anti-TROP2/HER3 antibody drug conjugate (ADC): Antitumor activity in patients (pts) with metastatic triple-negative breast cancer (mTNBC) and safety ...

Mice genetically engineered to lack the amino acid cysteine, and fed a cysteine-free diet, lost 30 percent of their body weight in a week.

By eliminating the essential amino acid cysteine from the diets of mice, and disabling their ability to produce it, scientists have induced rapid and dramatic weight loss. The technique opens a ...

The parametrization of the conjugation reaction through mechanistic kinetic models offers a chance to enhance valuable reaction knowledge and ensure process robustness. This study introduces a ...

The review explores the potential link between alopecia areata (AA) and cysteine metabolism. Research suggests insufficient cysteine levels or disruptions in its processing could contribute to AA ...

Abstract. Cisplatin is a chemotherapeutic agent used to treat many types of malignant tumors. However, irrespective of its potent anticancer properties and efficacy, nephrotoxicity is the ...

Development of a CUB domain-containing protein 1 (CDCP1)-targeting antibody-drug conjugate for triple-negative and metastatic breast cancer.