Patients with vitiligo experience impacts on quality of life, emerging therapies offer promising prospects for more targeted ...

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that ...

Researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. This crystalline arthritis is caused ...

The novel PDE10A inhibitor CPL'36 offers a new mechanism of action and is both safe and effective for acute exacerbations of schizophrenia, new research suggests.

Inobrodib is being developed as a first-in-class oral cancer drug that the company says will be able to treat not only multiple myeloma, but other specific cancers as well.

Abstract: Cyclic adenosine 3’,5’-monophosphate (cAMP) is a versatile secondary messenger that communicates with Guanine Nucleotide Exchange Factor (EPAC) to transfer cellular signaling and regulates ...

Using genetic and biochemical assays, we found that Acb2 bound the OptS-synthesized nucleotide, 2′,3′-cyclic adenosine monophosphate (2′,3′-c-di-AMP); however, 2′,3′-c-di-AMP was synthesized ...

The Significant Role of Cyclic Adenosine Monophosphate Additionally, and intimately connected to the critical roles that exercise and BDNF play in bringing about and enhancing the physiological ...

Patients are prone to airway contraction when cells lose cyclic adenosine monophosphate. Patients with asthma had higher average serum cAMP levels than patients who did not have asthma.

THE biologic role of cyclic AMP (adenosine 3′,5′-monophosphate), at least as it is understood today, is shown in Figure 1. After release from an endocrine gland, a hormone is transported to ...

The activation of this receptor increases levels of the intracellular signaling molecules, cyclic adenosine monophosphate (cAMP) and inositol triphosphate (IP3). Both cAMP and IP3 eventually ...