More information: Merve Demir et al, Structural basis for substrate binding, catalysis and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor, Structure (2025).

Lessons from the ribosome: A reflection on collaboration The ribosome’s structure exemplifies the complexity and beauty of molecular biology. Unravelling it required international collaboration ...

163.com Objective: To investigate the association between muscle-specific creatine kinase (CKMM) gene polymorphism and the effects of endurance training on running economy. Methods: 102 biologically ...

The U-M team suspected that certain fentalogs could potentially be used as antidotes to fentanyl, much in the way that naloxone, which has a chemical structure very close to morphine, is an ...

New research based on studies in both humans and mice shows that people with type 2 diabetes have lower protein levels in their muscles that metabolises and converts creatine - a protein called ...

a naturally occurring chemical found in your muscle cells. As a result, creatine turns into phosphocreatine — a high-energy substance used by your body to generate energy. While creatine kinase ...

Creatine can have a phosphate added to it using an enzyme called creatine kinase. The new molecule, called phosphocreatine, can then be used to regenerate ATP from ADP in places of high energy use ...

In the muscle, creatine is mainly in the form of phosphocreatine. This reacts with creatine kinase to form adenosine triphosphate (ATP), which muscles use for energy. In addition to providing ...

An open-label phase I study to evaluate the safety, tolerability and preliminary efficacy of YY001 in patients with advanced solid tumors. This is an ASCO Meeting Abstract from the 2024 ASCO Annual ...