Laboratory testing for coagulation factor deficiencies and inhibitors is important for diagnosing and monitoring inherited and acquired coagulopathies and for evaluating the causes of coagulation ...

The enzyme is called "coagulation factor XII" (FXII ... two generations of PhD students and post-docs to complete." With a potent FXII inhibitor in hand, Heinis's group wanted to evaluate ...

Endothelial cells also synthesize antithrombotic molecules, such as tissue factor pathway inhibitor, which inhibits activation of coagulation ... that is generally complete within 3–5 minutes.

The coagulation cascade is regulated by natural anticoagulants, such as tissue factor pathway inhibitor, the protein C and protein S system, and antithrombin, all of which help to restrict the ...

Production begins when tissue factor in the extrinsic coagulation pathway is exposed in a blood ... thought to be an advantage of direct thrombin inhibitors, since clot-bound thrombin retains ...

A cytokine receptor analogue on the surface of cells that initiates blood coagulation and is engaged in cell-signaling events. Tissue factor pathway inhibitor A protein that, when bound to factor ...

These factors form two cascades known as the intrinsic and extrinsic coagulation pathways. Both of these pathways lead to the formation of thrombin. The extrinsic pathway also facilitates the ...

Inflammation stimulates the expression of tissue factor and tissue factor pathway inhibitor (TFPI) by endothelial cells ... Mannheim, Germany). Complete blood counts were performed using a Sysmex ...

Background: PCI-27483 is a selective inhibitor of FVIIa, a serine protease activated ... ECOG performance status 0-1, and normal coagulation were enrolled. All pts in phase I and II receive ...

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape ...

Janssen Pharmaceutica NV has identified bicyclic pyridin-2-one and pyrimidin-4-one derivatives acting as coagulation factor XIa inhibitors and thus reported to be useful for the treatment of ...