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Nature1d
The laminin-binding domain of agrin is structurally related to N-TIMP-1
Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA ...
ahajournals.org1d
ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells
The magnified region depicts the ROCK2-interacting domain, including both inhibitory phosphorylation sites, and a predicted coiled coil region. When overexpressed in VSMCs, ROCK1 and -2 were localized ...
C&EN15d
Diabetes-Associated Mutations in Insulin: Consecutive Residues in the B Chain Contact Distinct Domains of the Insulin Receptor†,
Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4935, Department of Pharmacology and Biological Chemistry, Mt. Sinai School of Medicine of New ...
C&EN28d
Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening
Medicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary National Drug Research and Development Laboratory, HUN-REN Research ...