Chlorambucil (N,N-bis(2-chloroethyl)-p-aminophenylbutyric acid) is a bifunctional alkylating drug belonging to the nitrogen mustard group and is widely used as an anticancer agent. As the antitumor ...

Chlorambucil may be effective in some cases. Methotrexate is used for biopsy-confirmed sclerosing cholangitis. It is important to maintain adequate nutrition to prevent secondary hepatic lipidosis.

We describe a novel synthetic small molecule which shows an unprecedented stabilization of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA. We report that this ...