A Hong Kong University of Science and Technology (HKUST) research team has developed a catalytic enantioselective type II ...

Thus, developing a chemical synthesis reaction that selectively produces one enantiomer of chiral molecules useful in medicine is of great significance in the synthesis of drugs and their precursors.

Enantiomers, or molecule pairs that are mirror images of each other, make up more than half of FDA-approved drugs in use ...

Chirality is a critical factor in the discovery of drugs derived from natural products. Natural products are intricate organic molecules biosynthesized by living organisms, exhibiting a broad spectrum ...

Scientists at The Scripps Research Institute (TSRI) say they have invented a new technique for constructing chiral drug molecules, whose structural complexity allows them to have mirror-image ...

Chiral switches are chiral drugs that have already been claimed, approved and marketed as racemates or as mixtures of stereoisomers, but have since been redeveloped as single enantiomers.

Chiral molecules are those whose structural complexity allows them to have mirror-image, "left-handed" and "right-handed" forms. For drug molecules, usually only one of those forms works - the ...

The importance of chirality -- or 'handedness' -- in drug development was brought to light in a devastating way almost half a century ago with the development of the Thalidomide drug. Prescribed ...

At the time, large-scale asymmetric synthesis was impractical, so development of single-isomer drugs had to rely on inefficient chiral resolution. More recently, even with the emergence of new ...

The approach, which uses a nanostructure fabrication device, can manipulate the chirality of drug molecules by controlling the direction a substrate is rotated within the device, thus eliminating ...

Researchers have been actively looking for novel antitubercular medications with little side effects that are effective against drug-resistant strains to solve this problem. The usage of chiral drugs ...

One prominent example of a chiral switch occurred in 2001, when the US Food and Drug Administration (FDA) approved AstraZeneca’s esomeprazole (Nexium), a proton pump inhibitor (PPI) used to ...