Shitara Y, Hirano M, Sato H, Sugiyama Y. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated ...

Polymorphism of CYP2C8, CYP3A4 and SLCO1B1 were proven to be risk factors for rhabdomyolysis after taking cerivastatin. Cisapride was a substrate of CYP3A4, ...

Cerivastatin is a novel, potent hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor that effectively reduces serum cholesterol levels at low daily doses. [1,2,3] ...

Methods and Results Endothelium-dependent relaxation to acetylcholine and the calcium ionophore A23187 was reduced in aortic segments from hypercholesterolemic rabbits compared with controls.