This study presents compelling evidence that the denitrosylase SCoR2 regulates cardioprotective metabolic reprogramming in the heart following ischemia/reperfusion injury. The findings are supported ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

The Cyto-Mine Chroma platform uses fluorescence-based assays in picodroplets to select single cells based on secreted, surface, and/or intracellular markers. Aided by the new multiplexing capability ...

Here, we describe the development of a new panel of biochemical and cell-based assays to evaluate the binding and function of known chemical entities targeting mutant KRAS. Our assay panels generated ...

Therefore, image-based profiling allows researchers to make discoveries free of bias. The Cell Painting assay has become one of the most ... difference between cells from patients with a disease ...

The increase in disease burden, and the corresponding economic burden, has led to the growing use of cell-based assays ... data can be utilized to validate biochemical data and can reveal unknown ...

6 The National Taiwan University Hospital (NTUH) is one of the study sites for BFAST, and the blood-based NGS assay provided genomic alteration results for the enrolled patients. Our study aimed to ...

Measuring functional antibody blockade of the spike protein/ACE2 interaction is therefore likely to become increasingly important, and we envisage that this cell-based, spike protein interaction assay ...

among 3 assays used in suspected cases of myasthenia gravis. “Thus, the current guidelines for the diagnosis of MG generally lack evidence-based recommendations on methodology for detecting AChR ...