Time under tension (TUT) is a weightlifting technique designed to build muscle mass by increasing the time muscles spend activated during an exercise. We cover if it works and what its benefits are.

The tool is designed to inactivate non-muscle myosin II, responsible for actomyosin contractility. To achieve this, the scientists used a protein called MYPT1 that inactivates myosin.

Nonmuscle myosin II (NM II) is an integral part of essential cellular processes, including adhesion and migration. Mammalian cells express up to three isoforms termed NM IIA, B, and C. We used U2OS ...

All cell functions that involve membrane deformation or a change in cell shape (e.g., endocytosis, exocytosis, cell motility, and cytokinesis) are regulated by membrane tension. While molecular ...

The plus-end directed forces can combat the membrane tension to result in a net elongation of the protrusion in a mechanism similar to that proposed for myosin I and myosin X, whereby the motor is ...

Their results, published April 7 in Cell Reports, reveal that myosin-IIA generates cortex tension, while myosin-IIB maintains cortical stability.

DE‐Cadherin:mCherry shown in orange marks cell‐cell junctions. Myosin II Regulatory Light Chain (Sqh)‐GFP shown in magenta. By Tara Finegan, Dan Bergstralh and colleagues: Tissue tension and not ...

It is not yet determined if tensions are “absorbed” due to the elastic nature of microvilli, or if on the contrary, microvilli push against the antigen-presenting cells, thereby increasing the tension ...

Fly cells squeeze through tissue barriers in the body better when these barriers are made less stiff. This is the result of a study by Daria Siekhaus, Professor at the Institute of Science and ...

"The myosin pulls on the actin to provide tension in the membrane, and then that tension maintains the biconcave shape." The team then treated red blood cells with a compound called blebbistatin ...

We show that Ncad bonds contribute two fold less than Myosin-II (MyoII) to interfacial tension, but that Ncad also affects localization and levels of MyoII, and thus cell shapes. We reveal that ...