Researchers at MIT and other institutions have identified compounds that can fight off viral infection by activating a ...

Mantle cell lymphoma treatment offers options if patients relapse after CAR T-cell therapy, from bispecific antibodies, antibody drug conjugates, and other emerging therapies.

RNA bundled in lipid nanoparticles trains T cells in mice to eliminate cancer. Coupled with noninvasive imaging, researchers tracked the in situ CAR-T cells to assess their effectiveness and safety.

Amino acids play a fundamental role in regulating how cells respond to drugs. These molecules, which form proteins, act like ...

Investigating conserved signaling pathways in different cell types shows that memory is not a unique property of neurons.

A protein-engineering strategy, in which a constitutively active form of an immune receptor is kept inactive by a peptide ...

Scientists from the Centenary Institute and the University of Sydney have made a landmark discovery that could lead to safer ...

Characterization of intracellular synapse heterogeneity aides to understand the intricate computational logic of neuronal circuits. Despite recent advances in connectomics, the spatial patterns of ...

Allogeneic cell therapies are advancing in clinical trials, requiring oncologists and pathologists to understand the ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

The triggering receptor expressed on myeloid cells 2 (TREM2) plays a pivotal role in the activation of myeloid cells and is currently being investigated as a potential therapeutic target in several ...