The growing problem of antibiotic resistance has ... of proteins that are localized in the bacterial membrane. But where will the cell-division inhibitors come from? There is increasing evidence ...

Whakaihu Waka researchers have been part of two studies in the battle against drug resistant strains of Mycobacterium ...

The primary reason is that the inhibitors are unable to permeate through the bacterial membrane ... cell more effectively," says Dr. Hou. "Then, combining these inhibitors with traditional ...

Tuberculosis is the world's leading infectious cause of death, killing more than one million people each year. When the ...

Antibiotic resistance is a growing ... it could be an Achilles heel in the bacterial shield — inhibitors that access BamA would not need to penetrate the cell. Indeed, a proof-of-concept study ...

Some antibiotics, including tetracycline, which is used to treat acne, respiratory tract infections and other conditions, inhibit protein ... of a bacterium's cell membrane, which controls how ...

To fight this resistance, researchers are creating pharmaceuticals that attack and inhibit the ... cost of creating the antibiotic-degrading enzyme has left the resistant cell population depleted ...

But that process requires that antibiotic molecules cross the bacteria’s cell membrane to reach those ... our tools to develop new assays to find inhibitors for those enzymes.

unlike most antibiotics. On one hand, they bind to membrane lipids, destabilizing the bacterial membrane. Additionally, they inhibit two enzymes involved in cell wall and protein synthesis.

coli bacteria, and consider the protein a potential new target for antibiotics ... an extra membrane, called the outer membrane, that reduces the chances for a drug to penetrate the cell to ...

The drug works differently from currently available antibiotics ... developed drug uses a different tactic. It inhibits a key enzyme in the cell membrane that helps the bacteria secrete proteins.

which could be a potential new target for antibiotics. In the study, the researchers confirmed that this protein, called MurJ, flips a fatty molecule from one side of a bacterial cell membrane to ...