Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity ... Mitotic progression requires that several checkpoints are silenced, the most prominent of ...

The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

The checkpoints are molecular mechanisms that ... you would expect them to be passive," Bhalla said. "When you see cell division, with the chromosomes lining up and segregating, it seems like ...

"We found that Cyclin B has a crucial role in activating a checkpoint that stops division until the cell is ready to divide correctly," said Dr. Saurin. "This is important because otherwise the ...

A newly described small molecule inhibitor called AOH-1996 targets a cancer-associated isoform of PCNA (caPCNA), leading to a very broad therapeutic window.

A new study challenges a widely-held notion about cell division. © screenshot from a video by The University of Manchester, with photo editing by Gizmodo If you took ...

A review discussing the therapeutic potentials of NK cell biology has been published in the journal Frontiers of Medicine. This exhaustion is influenced by immune checkpoint receptors, which are ...

This exhaustion is influenced by immune checkpoint receptors, which are inhibitory cell surface receptors that can suppress antitumor immunity. Notably, intracellular checkpoint molecules within ...

All cells are produced from other cells by the process of cell division. Cell division occurs when one cell divides to produce two new cells. Unicellular organisms use cell division to reproduce.