As cells divide, they must copy all of their chromosomes once and only once, or chaos would ensue. How do they do it? By Amber Dance/Knowable Magazine Published Jul 7, 2023 6:00 PM EDT This ...

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and ...

T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into ...

Each cell division is accompanied by DNA replication, ensuring that each daughter cell contains a copy of the whole genome. In their new study, the team of RIKEN BDR researchers set out to ...

However, incomplete DNA replication or chromosome entanglement can result in the formation of DNA bridges between two daughter cells. If these bridges are not properly resolved, it can lead to ...

replication stress is when the process of DNA replication — by which DNA is duplicated during the cell cycle — is slowed down or halted due to issues that arise with the DNA synthesis process.

Subscribe for FREE Using cultured human cells with genome-edited TEFM knockout ... alongside a decrease in 7S DNA levels and strand-asynchronous replication intermediates. These findings suggest that ...

10.1016/j.cell.2024.07.017]. The scientists determined that Mrc1 and Mcm2 form a co-chaperone complex, ensuring distribution of histones to the lagging strand during DNA replication. In mutants of ...