Neoadjuvant nivolumab (Opdivo) plus chemotherapy significantly improved overall survival (OS) compared with chemotherapy ...

(UroToday.com) The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, held in Chicago, IL, was host to a kidney and bladder cancers oral abstract session. Dr. Tian Zhang discussed the ...

A new study finds a link between different stages of the menstrual cycle and pain crises in sickle cell disease. (Image credit: KATERYNA KON/SCIENCE PHOTO LIBRARY via Getty Images) Pain crises are ...

The expression levels of cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors as well as functions of the cell cycle checkpoints determine whether the cell cycle progression is smooth.

Note: These checkpoints play a crucial role in ensuring the proper progression of the cell cycle and preventing the cell from entering the next phase if any abnormalities or errors are detected. The ...

Measuring COVID-19's impact on diagnosis of cervical cancer by race/ethnicity, age, and region of the United States. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract ...

The cell cycle is a complex process regulated by checkpoints and restriction points, consisting of multiple stages. Regulatory mechanisms ensure smooth and error-free progression of the cell cycle. In ...

However, regulation of these cell cycle changes is poorly understood, especially in mammals. Checkpoint kinase 1 (CHK1) is a protein kinase that regulates cell cycle progression in somatic cells. Here ...

Through these events, normal cells can become malignant. PT162 was designed to act as a p53-reactivating cell cycle checkpoint inhibitor, inducing cancer cell cycle arrest and/or apoptosis by ...