The term ‘cell-cycle checkpoint’ refers to mechanisms by which the cell actively halts progression through the cell cycle until it can ensure that an earlier process, such as DNA replication ...

CDKs function to phosphorylate many different proteins which are required for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the end of G1 and the ...

Through these events, normal cells can become malignant. PT162 was designed to act as a p53-reactivating cell cycle checkpoint inhibitor, inducing cancer cell cycle arrest and/or apoptosis by ...

The stages of this cycle include ... Finally, M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint. They aid the formation of spindles and chromosome ...

Thus, abrogation of cell cycle checkpoints, before DNA repair is complete, can activate the apoptotic cascade, leading to cell death. Now in clinical trials are a series of targeted agents that ...

From this and other discoveries, including the discovery of the RAD9 gene with former postdoc Ted Weinert, Hartwell hypothesized that checkpoints regulate the sequence of events in mitosis.1 His ...

In essence, cell cycle arrest at these critical checkpoints represents a survival mechanism, which provides the tumor cell the opportunity to escape the effects of lethal DNA damage induced by ...

Loss-of-function variants in genes encoding tumor suppressor proteins, such as those that mediate DNA repair and cell-cycle checkpoints, can also contribute to an unstable genome. A gene that ...

With so much at stake, nature keeps it tightly controlled in a process called the cell cycle that scientists thought they thoroughly understood. But now it turns out there was more to know. Scientists ...

The book on ‘Cell Cycle Checkpoints and Cancer’, edited by Mikhail Blagosklonny, is such a brave attempt, and a very successful one indeed. The editor himself is one of the recognized leading ...