No cases of neutropenia were reported for the 121 courses of antimicrobials other than cefepime. Among the 13 courses of cefepime therapy, 8 resulted in neutropenia after an average of 25 days of ...

Single-molecule biophysics is the study of the dynamics and interactions of individual biomolecules to understand how they carry out their functions in living cells. For example, monitoring the ...

Molecular Psychiatry publishes work aimed at elucidating biological mechanisms underlying psychiatric disorders and their treatment. The emphasis is on studies at the interface of pre-clinical and ...

The three platform deals are long-term bets, but broaden Genentech’s drug discovery capabilities, particularly in small-molecule R&D. The Convelo deal focuses on the development of novel drug ...

While this is considered clinically significant, it is unknown how often ceftriaxone induces such substantial increases in hepatic transaminase levels. Our patient had severe meningitis ...

The FDA has given the green light to Exblifep, based on long-established beta-lactam antibiotic cefepime and a new extended-spectrum beta-lactamase inhibitor (BLI) called enmetazobactam ...

Here, we describe the discovery of novel WDR5 inhibitors for the other WBM (WDR5 binding motif) pocket on this scaffold protein, to disrupt WDR5 interaction with its binding partner MYC by ...

Save guides, add subjects and pick up where you left off with your BBC account. Covalent bonds Modelling molecules Drawing dot and cross diagrams Interpreting dot and cross diagrams Properties of ...