A study led by clinician-scientists and researchers at the National Cancer Centre Singapore (NCCS) has found that the tumor immune microenvironment (TIME) plays a critical role in the progression of ...

Colorectal cancer highlights from ASCO 2025 include findings from the BREAKWATER, ATOMIC, DYNAMIC-III, and TRIPLETE trials.

Several chemotherapeutic agents interact with warfarin. 78–84 Two fluoropyrimidines in particular have been widely reported to interact with warfarin: fluorouracil and capecitabine. 78,80 Fluorouracil ...

Objective Neratinib plus capecitabine (Ner+Cap) were proved to be clinically beneficial as a third-line treatment for women with human epidermal growth factor receptor-2 (HER2) positive metastatic ...

Capecitabine. Capecitabine is an oral prodrug that is converted to 5-FU via thymidine phosphorylase. Radiation has been shown to preferentially increase tumor thymidine phosphorylase levels via ...

A mum thought muscle ache and a pea-sized lump in her left breast was due to exercising too hard before discovering it was a ...

Capecitabine is an orally administered prodrug of 5-FU. The direct mechanism of action of capecitabine leading to vasoconstriction is not well-documented in the literature . However, the role of its ...

On Jan. 24, the FDA issued a warning about the enzyme deficiency in which it urged health care providers to “inform patients prior to treatment” about the risks of taking 5-FU and capecitabine. On ...

Around 300,000 people are treated with 5-FU or capecitabine in the United States each year, but its toxicity could well have prevented FDA approval were it up for approval today. Short of withdrawing ...