Fifty years ago, Bernard Katz's seminal work revealed that calcium triggers neurotransmitter release by stimulating ultrafast synaptic vesicle fusion. But how a presynaptic terminal achieves the ...

Here I discuss aspects of Miledi's research that helped to establish the requirement of presynaptic calcium for neurotransmitter release, from his earliest scientific studies to his classic ...

A new study uncovers critical aspects of calcium channel function ... Ca 2+ channels for the regulation of abundance and neurotransmitter release. Moreover, it identified a completely different ...

The calcium channels, when open, allow for the release of neurotransmitters. "Increases in acidity in the extracellular environment produced by the glial cells forms a feedback loop which prevents ...

A new study conducted by researchers at the Max Planck Florida Institute for Neuroscience uncovers critical aspects of calcium channel ... variability in neurotransmitter release during neuronal ...

They found that clusters with more calcium channels more effectively trigger a nearby vesicle to release neurotransmitters. Importantly, channel clusters closer to vesicles trigger ...

Calcium channels play a central role in pain signaling, in part through the release of neurotransmitters such as glutamate and GABA -- "the currency of the pain signal," according to Rajesh Khanna ...

When the calcium comes, we need a fast neurotransmitter release. Nature then invented synaptotagmin-1 to respond to the calcium. It's a trigger. The molecule is turned on and interacts with both ...

The team then used imaging techniques to measure acetylcholine levels and calcium influx. Calcium is essential for neurotransmitter release. In the eIF4E mice, acetylcholine binding to dopamine axons ...

Samuel Young Jr., Ph.D. set out to understand voltage-gated calcium (Ca2+) channel function, which determines the characteristics of neurotransmitter release and ultimately how the brain operates.