About CG-0416‌ CG-0416 is a novel liver-targeted THR-β prodrug in development for MASH & obesity-related complications. Its tissue-selective activation mechanism simultaneously addresses hepatic lipid ...

Non-CG methylation starts earlier in HPC inhibitory and excitatory neurons than in PFC neurons, with significant non-CG methylation observed in the HPC by the 39 th gestational week (GW).

Surprisingly, this does not require SHH1, the RdDM component that binds H3K9me. Furthermore, H3K9me is dispensable for RdDM, as is CG DNA methylation. Instead, we find that non-CG methylation is ...

Interestingly, convergent evolution of methylation at the whole-gene level is uncoupled from evolution of individual methylated CG sites. Only eight out of the 8,987 conserved CG sites among all ...

The methylation levels in the CG contexts were higher than that of CHG and CHH, with the highest methylation level of gene body region, followed by transcription termination sites and downstream.

process non-CG methylation (8-non_CG_methylation.R - no analyses implemented) check the results back into the object store (dtool) This workflow is carried out batch-wise to limit primary disk space ...

CG methylation (mCG) is found in all vertebrate cell types. It is known to be involved in long-term gene silencing processes. In vertebrates, ∼80% of all genomic CG dinucleotides are methylated.

In plants, CG methylation tends to be found within the transcribed gene bodies of particular genes, while CG, CHG, and CHH methylations are found together at RdDM sites, TEs, and heterochromatin ...

To investigate non-CG methylation further, the researchers conducted a comprehensive profiling of the zebrafish genome, a vertebrate organism that is a distant evolutionary relative of humans and ...

One example is methylation at non-CG sites in human brain cells, aberrations of which have been linked to Rett Syndrome, a genetic disorder that impairs growth, movement and speech in children.

Non-CG methylation appeared to depend on a few methyltransferases in particular, namely the DNA methyltransferases complex, i.e., the Dnmt3s-Dnmt3L complex. In contrast, ...