In fighting chronic infections or certain cancers, CD8+ T cells—the immune system's frontline soldiers—eventually become ...

HIV antivirals may be the key to stopping HTLV-1, a deadly virus with no cure. In a decade-long study, researchers successfully suppressed the virus in mice and discovered a way to kill infected cells ...

In the ongoing fight against HIV, scientists have taken a new step toward long-term control of the virus. Researchers have found a way to force HIV into a deep, long-lasting sleep by using a molecule ...

In this study, we aimed to characterize the viral reservoir and HIV-specific CD8+ T-cell responses in participants of the Netherlands Cohort Study on Acute HIV Infection (NOVA study), who initiated ...

The authors also showed that functional HIV-specific CD8⁺ T-cell responses persisted over three years and that early CD8⁺ T-cell proliferative capacity was linked to reservoir decline, supporting ...

The U.S. Food and Drug Administration has paused Gilead Sciences' trials testing a combination of two of its experimental HIV treatments due to low levels of a type of white blood cell in some ...

HIV targets and destroys these CD4 + T cells—key players in the immune response—weakening the body's ability to fight infections and certain cancers.

A panelist discusses how CD4 counts serve as measures of immune system status that typically increase by about 200 in the first year of antiretroviral therapy. Although there can be laboratory ...

Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced (armore ...

Supporting the role for macropinosomes, inhibition of macropinocytosis prevents HIV-1 internalization into, fusion with, and infection of primary CD4 + T cells. By contrast, infection of a CD4 + T ...

Immunological non-responders (INRs) are people living with HIV-1 who fail to achieve full immune reconstitution despite long-term effective antiretroviral therapy (ART). This incomplete recovery of ...