We found that 93 protein-coding cancer genes carried probable driver ... understanding of the origins and consequences of somatic mutations in breast cancer. Figure 3: Extraction and contributions ...

Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. Here we describe ...

Oncotarget published "Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients" which reported that the association between genetic ...

Recent research and genomic studies have revealed a number of genes that accumulate somatic, or non-inherited, mutations and alterations in estrogen receptor positive (ER+) breast cancer.

mutation carriers with metastatic breast cancer (MBC). In addition, PARPi have demonstrated efficacy in patients with ovarian cancer with somatic BRCA1 or BRCA2 (sBRCA1/2) mutations. Other genes also ...

Neuromedin U to increase IL-6 levels and to expand cancer stem cells in HER2-positive breast cancer cells. Effects of 2 hotspot HER3/4 mutations on response to TKI’s (nM) in vitro in transfected (MUT) ...

Breast cancer can run in families ... to cancer are acquired during your lifetime. These are called somatic mutations. Somatic mutations happen due to things like the natural aging process ...

A small proportion of women who receive anti-estrogen treatment after breast cancer surgery have worse outcomes. This is associated with mutations in the estrogen receptor gene, according to a ...

BRCAness refers to tumors that mimic BRCA1/2 mutation behavior, making them vulnerable to DNA-damaging treatments like PARP ...

“Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models [...].” Somatic HER2 mutations are a novel class ...

A new editorial paper was published in Oncotarget's Volume 14 on October 31, 2023, entitled, "The uncharted role of HER2 mutant alleles in breast cancer." Somatic HER2 mutations are a novel class ...