The privately funded basket trial makes good on its aim to enroll underrepresented groups amid a DEI-hostile federal funding ...

Triple-negative breast cancer (TNBC) comprises 10–15% of all breast cancers. It is a very heterogeneous disease, ...

Stanford Medicine has analyzed thousands of breast cancer tumors and found that gene variants can predict the types and ...

Brk (breast tumor kinase, also known as PTK6) is a nonreceptor tyrosine kinase that is aberrantly expressed in several cancers and promotes cell proliferation and transformation. Genome sequencing ...

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more ...

Randee’s cancer had metastasized. When her doctor tested her for the PIK3CA gene mutation, she was able to make informed decisions about her disease journey.

Dr. Evan Yu presents the new evidence-based guideline on genetic testing for metastatic prostate cancer. He discusses who should receive germline and somatic testing with next-generation sequencing ...

Researchers have pinpointed what could be the early genetic origins of breast cancer -- cancer-like mutations appearing in the cells of healthy women. In a new study, the international ...

Abstract. Carcinogenesis centers on principles of somatic evolution, where a cell gradually accumulates mutations, eventually transforming into a tumor cell. Exploring somatic variation in the healthy ...

Specifically, two categories of mutations — germline mutations and somatic mutations — may increase an individual’s risk of developing breast cancer.

Researchers examine the interplay of germline cancer risk mutations and somatic mutations, and how surgery type and contraceptives impact breast cancer risk.

A new editorial paper was published in Oncotarget's Volume 14 on October 31, 2023, entitled, "The uncharted role of HER2 mutant alleles in breast cancer." Somatic HER2 mutations are a novel class ...