Proteins enter this compartment as extended polypeptides and fold into their functional state in a process that is assisted by lumenal chaperones such as BiP. The protein folding machinery of the ...

Additionally, recombinant BiP, an ER-resident chaperone ... More information: Claudio Hetz et al, Essential roles of the unfolded protein response in intestinal physiology, eGastroenterology ...

BiP binding seems to be directly proportional ... which serves to tag misfolded protein for degradation by a proteasome-mediated pathway. A similar dependence on mannosidase I activity was ...

Nat Struct Mol Biol 2018; 25(1): 90–100. 20. Chung KT, Shen Y and Hendershot LM. BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. J ...