Indole-based alkaloid natural products such as fischerindoles and hapalindoles have promising antimicrobial and antitumor activities, but they are difficult to make synthetically. New findings on ...

Several expensive anticancer alkaloid blockbusters used in chemotherapy, such as terpenoid indole alkaloids -- vinblastine and vincristine, are currently extracted from the plant Catharanthus ...

The SmartCell Consortium succeeded in elucidating the complete upstream segment of the terpenoid indole alkaloid biosynthesis pathway, as described in a ground-breaking article published in the ...

Synthetic Biology Provides New Path for Environmentally Friendly and Affordable Anti-Cancer Drug Vinblastine Production. September 6, 2022. ... Monoterpenoid indole alkaloids (MIAs) ...

Inspired by nature’s biosynthesis of indole alkaloids, Chang and Toste’s team developed an N-sulfonyl oxaziridine reagent that reacts selectively and quickly with tryptophan residues that are ...