In addition, these cells display a reduced capacity to produce cytokines and lower survival rates than wild-type cells. Our findings indicate that these effects are mediated by defective lipid ...

The findings suggest that lipid metabolism may play a central role in maintaining a healthy immune system as we age.

Fat metabolism is a fascinating process and essential for human survival. It involves the digestion, absorption, transportation and utilization of lipids as a source of energy or as an energy reserve.

This study reports a successful adaptation of an inquiry-based laboratory experiment for a qualitative evaluation of the factors that affect lipid oxidation. The experiment was implemented in two ...

Lipid nanoparticles have various metabolism routes, which can depend on the delivery method and target site. These routes include oral, intravenous, transdermal and intramuscular delivery systems and ...

Takahashi isolated the brains of 12-month-old TMEM106b-deficient and wild-type mice, homogenized the tissue, and measured lipid content by mass spectrometry. Why lipids? Because their metabolism ...

This blocking can also impair mitochondrial beta-oxidation and increase the accumulation of toxic lipids, such as ceramide and ROS, by inhibiting the lipid oxidase CPT1 (etomoxir) (254).

Scientists provide a detailed overview on age-related alterations in lipid metabolism and its association with age-related chronic diseases.

The identification of OGFr as a crucial player for enhancing lipid oxidation provides a new avenue for addressing obesity and related afflictions.

Similarly, as lipotoxicity leads to inflammation, lipid metabolism changes can result in immune system alterations. This results in a vicious cycle that can lead to several chronic diseases.

Thus, imbalances in lipid homeostasis can result in toxicity and contribute to SLE (11). Growing evidence suggests lipid-mediated activities in immunocytes and the critical role of lipid metabolic ...