A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

An easy method for efficiently identifying proteins that interact with bioactive molecules has been developed by chemical biologists at RIKEN. This innovation, published in ChemBioChem, could help to ...

This newly found organism doesn’t act like a virus or a cell, and that could change everything we know about biology.

In the present study, restrained and unrestrained molecular dynamics simulations, carried out using multiple nucleic acid force fields, are used to demonstrate that partial base-flipping can be ...

Evo is a large language model that is not trained on words but on the genomes of millions of microbes. It can accurately predict the effects of mutations.

Credit: Kateryna Kon/Science Photo Library/ What is DNA, and how does it work? You don't need a degree in genetics to understand. Here, we'll give an overview of DNA and answer questions ...

The little fern from New Caledonia is just a few inches tall, and its genome has 160.45 billion base pairs—50 times more DNA than a human.

The plant's genome has about 50 times as many base pairs as a human's, and its DNA from a single cell would stretch longer than a football field ...

The plant (Tmesipteris oblanceolata) contains a whopping 160 billion base pairs, the units that make up a strand of DNA.

DddA-half-preference was defined when pairs derived from the same split can both edit effectively for a specific strand but the editing efficiency of one pair is always higher than that of the other ...

The base editing technique enables precise modification of the human genome by achieving targeted conversion independent of HDR and double-strand DNA breaks, directly altering individual base pairs ...

Finally, the cell’s own DNA repair machinery completes the editing process by incorporating the edited DNA strand, resulting in the desired modification to the genome. Much like with base editing, the ...