In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from ...

Brain metastases are a common problem in patients with EGFR-mutated non-small cell lung cancer (NSCLC), occurring in about ...

Park SJ, Kim HT, Lee DH, et al: Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 ...

At the beginning of my career as an oncologist in the late 1980s, brain metastases were often considered an “end of the road” diagnosis. Yes, there was the rare metastases resection or whole brain ...

However, case reports, as well as a small retrospective study, have suggested that cabozantinib can cross the blood-brain barrier and treat brain metastases, the team added.. The new multicenter ...

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient ...

The incidence of brain metastasis (BM) is high in patients with non-small-cell lung cancer. Available standard therapeutic options, such as whole-brain radiation therapy and systemic chemotherapy ...

The candidate is an orally administered selective tyrosine kinase inhibitor that targets HER2. Designed to cross the blood-brain barrier, ZN-A-1041 could reach metastatic cancer cells and bind to ...

From these, they developed a cell line that led to brain metastasis in 100% of the mice when injected into the breast tissue, giving them a model that more closely resembled the metastatic pathway ...

Brain metastases, as these secondary tumors are called, most commonly arise from solid tumors like breast, lung, and colon cancer and are often associated with a poor prognosis.

Brain metastases are a common problem in patients with EGFR-mutated non-small cell lung cancer (NSCLC), occurring in about one-fifth to one-quarter of patients. Many brain metastases will be ...