In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from ...

Brain metastases are a common problem in patients with EGFR-mutated non-small cell lung cancer (NSCLC), occurring in about ...

PurposeStereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for brain metastases in ...

At the beginning of my career as an oncologist in the late 1980s, brain metastases were often considered an “end of the road” diagnosis. Yes, there was the rare metastases resection or whole brain ...

However, case reports, as well as a small retrospective study, have suggested that cabozantinib can cross the blood-brain barrier and treat brain metastases, the team added.. The new multicenter ...

Brain metastases, as these secondary tumors are called, most commonly arise from solid tumors like breast, lung, and colon cancer and are often associated with a poor prognosis.

The candidate is an orally administered selective tyrosine kinase inhibitor that targets HER2. Designed to cross the blood-brain barrier, ZN-A-1041 could reach metastatic cancer cells and bind to ...

From these, they developed a cell line that led to brain metastasis in 100% of the mice when injected into the breast tissue, giving them a model that more closely resembled the metastatic pathway ...

The incidence of brain metastasis (BM) is high in patients with non-small-cell lung cancer. Available standard therapeutic options, such as whole-brain radiation therapy and systemic chemotherapy ...

PurposeStereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for brain metastases in ...

Brain metastases are a common problem in patients with EGFR-mutated non-small cell lung cancer (NSCLC), occurring in about one-fifth to one-quarter of patients. Many brain metastases will be ...