that disrupts its kinase activity failed to fully activate YAP activity in the reporter system (Figure 3g). These results suggest that Aurora A signaling can positively regulate YAP-directed gene ...

The Aurora A kinase may contribute to polycystic kidney ... Because both calcium signaling and cilia are defective in PKD, researchers from the Fox Chase Cancer Center in Philadelphia wondered ...

PHILADELPHIA – In preclinical models, combining an investigational Aurora Kinase A (AURKA ... protein downstream of KRAS that amplifies RAS signaling and is also involved in regulating cell ...

They identified and tested aurora kinase inhibitors ... studies should examine opportunities to similarly intervene in signaling by immune cells or other cells in the surrounding tumor stroma ...

AURKA inhibitors might enhance outcomes of metastatic prostate cancer treated with androgen receptor pathway inhibitors by intensifying androgen receptor inhibition, increasing DNA-damage-related cell ...

About Aurora A Kinase Aurora A kinase (AURKA ... includes degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene ...

Aurora A overexpression correlates with poor prognosis and is considered a therapeutic target for cancer treatments, although the clinical development of Aurora kinase inhibitors has been so far ...

In preclinical models, combining an investigational Aurora Kinase A (AURKA ... resistance can develop rapidly through adaptive signaling mechanisms that lead to reactivation of mutant KRAS ...