We studied two unrelated subjects with a deficiency of aquaporin-1 and found that they had impaired urinary concentrating ability, suggesting that aquaporin-1 has a physiologic role in renal function.

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Studies on the function of aquaporin-1 (AQP-1), which is located in the alveolar epithelial cells of the lung, may provide insights leading to the design of novel therapeutic approaches for lung ...

Aquaporin-1 is also highly expressed in the endothelium lining peritoneal capillaries, where it facilitates osmotically driven water transport during peritoneal dialysis.