We studied two unrelated subjects with a deficiency of aquaporin-1 and found that they had impaired urinary concentrating ability, suggesting that aquaporin-1 has a physiologic role in renal function.

Studies on the function of aquaporin-1 (AQP-1), which is located in the alveolar epithelial cells of the lung, may provide insights leading to the design of novel therapeutic approaches for lung ...

To the Editor: In their review article on water balance, Knepper et al. (April 2 issue)1 discuss water channels (aquaporins) in renal tubular cells. They omit mention of the critical role played by ...