Schizophrenics who took the newer antipsychotic drugs along with the nicotine patch had nearly triple the success rate quitting smoking as schizophrenics taking more traditional antipsychotic ...

NMRA-861 has potential best-in-class pharmacology, which may enable a more favorable therapeutic profile No convulsions ... While most current antipsychotics approved for schizophrenia work primarily ...

NMRA-861 may offer a more favorable therapeutic profile with fewer side effects compared to traditional antipsychotic treatments. What is the significance of the M4 muscarinic receptor in ...

While most current antipsychotics approved for schizophrenia work primarily by blocking D2 dopamine receptors, growing evidence supports the approach of targeting the M4 muscarinic receptor to ...

NMRA-861 is a highly potent and selective positive allosteric modulator (PAM) of the M4 muscarinic receptor with potential best ... and may offer an improved therapeutic profile relative to current ...

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Pharmacology Although the exact mechanism of action of antipsychotics has not been established, they are thought to exert their antipsychotic effects by blocking the dopamine type 2 (D 2) receptor ...

Given its receptor profile, dexmedetomidine does not increase the risk for respiratory compromise when combined with benzodiazepines.