Atomic structure of antifungal drug confirms unusual mechanism, opens door to less-toxic derivatives. ScienceDaily . Retrieved April 9, 2025 from www.sciencedaily.com / releases / 2021 / 12 ...

The 'orotomides', discovered by F2G Limited, have a novel mechanism of action which is the specific biochemical interaction through which a drug substance produces its pharmacological effect.

Like other microorganisms, fungi exist in populations that are adaptable. Under the selection imposed by antifungal drugs, drug-sensitive fungal pathogens frequently evolve resistance. Although ...

Atomic structure of antifungal drug confirms unusual mechanism, opens door to less-toxic derivatives Peer-Reviewed Publication. University of Illinois at Urbana-Champaign, News Bureau ...

An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic, claims a German-Austrian research team led by the Leibniz Institute for Natural ...

Engineers at Brown University have designed a nanoscale drug delivery system that enhances the effectiveness of an antifungal drug against Candida species, including drug-resistant strains such as ...

A team of leading infectious disease scientists from academia and industry have been awarded £17.9 million to identify new ...

Enter a new antifungal, mandimycin. It’s the latest addition to a group of antifungals called glycosylated polyene macrolides, but it works differently from the rest.

The Food and Drug Administration (FDA) has granted Fast Track designations to both the oral and intravenous formulations of fosmanogepix (APX001; Amplyx Pharmaceuticals) for 7 antifungal ...

Every year, life-threatening invasive fungal infections afflict more than 2 million individuals globally. Mortality rates for these infections are high, even when patients receive treatment.

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial ...

Engineers at Brown University have designed a nanoscale drug delivery system that enhances the effectiveness of an antifungal drug against Candida species, including drug-resistant strains such as ...