Tricyclic antidepressants (TCAs) were among the first drugs developed to treat depression. They’ve been on the market since the 1950s. TCA mechanism of action ...

Researchers have reported progress in the important effort to explain the rapid antidepressant action of ketamine, and in so doing, have gained insights that may inform the development of other ...

While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use.

The correlation between serotonin and depression is highly debated and is relevant for diagnosis, treatment, and drug development. To better study this area, a Chinese team has now developed a ...

Understanding a drug’s mechanism of action (MOA) can greatly increase the likelihood of successful clinical trials by identifying biomarkers of patient response and providing a rationale for ...

Auvelity, from Axsome Therapeutics, marks the first drug with a different mechanism of action approved for treating depression in 60 years. In clinical trials, participants reported… ...

Yet their mechanisms of action—and their wider effects across the body—are still ... we are excited to explore whether antidepressants may help deliver drugs into other hard-to-reach corners ...

Although the precise mechanism that ketamine uses to reduce depression symptoms isn’t fully understood, the drug has been shown to have remarkably fast and powerful antidepressant effects in ...

Research in animals has shown that the diabetes drug dulaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist may reduce symptoms of depression.

Auvelity is a new, fast-acting drug used to treat major depressive disorder or clinical depression. It is the first pill in more than 60 years with a new action to treat the condition.

For decades, tianeptine was used to treat depression, even though no one knew how it worked. But it turns out it's a type of opioid, and the U.S. is facing a spike in abuse of "gas station heroin." ...

To assess antidepressants’ potential effects on antibiotic resistance, Guo’s lab grew E. coli in the presence of physiologically relevant concentrations of five commonly prescribed ...