E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. However, the ...

“PDI is like a double agent,” Dr Shadfar explains. “In healthy cells, it repairs DNA and helps prevent disease. But in cancer, it gets hijacked — it ends up protecting the tumour instead of the body.

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Analysis of molecular glue-induced ternary structures reveals two potential pathways for complex formation, ... While ifenprodil has demonstrated neuroprotective efficacy in animal models of injury, .

Scotland’s largest animal welfare charity has warned against the illegal use of glue traps for pest control, after a series of incidents that have caused the deaths of birds and other wildlife.

HENRICO COUNTY, Va. (WRIC) — The Henrico County Police Animal Shelter cared for a baby rat snake that was found in a sticky situation. In a Facebook post on Thursday, June 5, the shelter said ...

In 2023, pressure on Bunnings to stop selling animal glue traps proved effective, with the retailer confirming they would phase them out. These products had been linked to wildlife harm, ...

Were you Seen at The Mohawk Hudson Humane Society Benson's Pet Center 2025 Gala for Animals on May 31, 2025, at the Albany Capital Center?

AIM To investigate the APO*E3-Leiden mouse as an animal model for age related maculopathy (ARM) related extracellular deposits. METHODS Eyes were obtained from APO*E3-Leiden transgenic mice on a high ...

Dangerous Animals, 2025. Directed by Sean Byrne, Starring Hassie Harrison, Jai Courtney, Josh Heuston, Ella Newton, Liam Greinke, Jon Quested, Giorgia Stawaruk, and Rob Carlton. SYNOPSIS: When ...

Owners of the House of Wiggle Goats rescue in Lansdale, Pennsylvania said a massive fire that killed dozens of animals was the result of an electrical issue.

Not-E3 2025 Showcases Schedule: June 3. State of Unreal 2025 - 6:30am PT / 9:30am ET / 2:30pm UK (YouTube, Twitch) Best Indie Games Summer Showcase 2025 - 8am PT / 11am ET / 4pm UK ; ...