The Anaphase Promoting Complex/Cyclosome (APC/C) plays an indispensable role in regulating timely cell cycle transition from mitosis to G1 phase. APC/C is a multi-subunit ubiquitin E3 ligase that ...

Aqueous zinc-ion batteries have gained significant attention due to their high safety and low cost. However, the cation concentration gradient at the anode/electrolyte interface often causes serious ...

Reviewer #2 (Public review): Summary: The authors took a well-characterised (partly by them), important E3 ligase, in the anaphase-promoting complex, and decided to design peptide inhibitors for it ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway by affecting the UFL1 ubiquitination [abstract]. In: Proceedings of the AACR Special Conference in ...

Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program. Considering the cell cycle, the ...

Overview of a RING E3 Ub ligase mechanism and structural overview of the Anaphase-Promoting Complex/Cyclosome (APC/C). (A) Substrate ubiquitination occurs through an E1-E2-E3 cascade, with RING E3s ...

The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions during mitosis. Here we identify the transcriptional regulator, transcriptional intermediary factor 1γ ...

Abstract The mitotic (or spindle assembly) checkpoint system ensures accurate segregation of chromosomes by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle. This ...

GPC1 inhibits the anaphase promoting complex/cyclosome (APC/C) mediated degradation of mitotic cyclins and securin. High-levels of GPC1 induce metaphase arrest and centrosome overproduction, ...