Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s,” Charles Piller looks how the amyloid hypothesis took over ...

The beta amyloid peptide (Abeta) is the primary component of the ... We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

Ever since Alois Alzheimer first described the neurological changes that characterize the disease that now bears his name, amyloid plaques ... s targeting of Aβ oligomers, has opened the ...

Explore the potential of monoclonal antibodies in Alzheimer’s treatment, including breakthroughs and challenges in this ...

Amyloid-beta is a protein fragment naturally produced ... Alzheimer’s begins when Aβ42 molecules stick together to form clumps called oligomers. These oligomers aggregate into amyloid plaques ...

This allows copper and zinc to react with Aβ released into the synaptic cleft to form oxidized, cross-linked soluble oligomers and precipitated amyloid. While the soluble Aβ monomers are ...

generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques ...

With UdeM professor Jonathan Brouillette, Mongrain said she's "looking to identify biomarkers present at the onset of ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that ...

Amyloid-beta: As Alzheimer’s disease develops ... The scientists focused on the “building blocks” of NFTs, including ...

Most pathological aggregates, called oligomers, are difficult to study ... developed can target different assemblies of amyloid-beta and alpha-synuclein, proteins associated with Alzheimer's ...