Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s,” Charles Piller looks how the amyloid hypothesis took over ...

The beta amyloid peptide (Abeta) is the primary component of the ... We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, which is blocked by the G37L ...

Amyloid-beta is a protein fragment naturally produced ... Alzheimer’s begins when Aβ42 molecules stick together to form clumps called oligomers. These oligomers aggregate into amyloid plaques ...

Explore the potential of monoclonal antibodies in Alzheimer’s treatment, including breakthroughs and challenges in this ...

generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques ...

This allows copper and zinc to react with Aβ released into the synaptic cleft to form oxidized, cross-linked soluble oligomers and precipitated amyloid. While the soluble Aβ monomers are ...

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that ...

With UdeM professor Jonathan Brouillette, Mongrain said she's "looking to identify biomarkers present at the onset of ...

The factor that tips you over the edge from being at risk for a disease to actually developing the disease is not always ...

Most pathological aggregates, called oligomers, are difficult to study ... developed can target different assemblies of amyloid-beta and alpha-synuclein, proteins associated with Alzheimer's ...

Amyloid-beta: As Alzheimer’s disease develops ... The scientists focused on the “building blocks” of NFTs, including ...