An example of a functionalized Grignard reagent prepared from 4-bromobenzonitrile and i-PrMgCl·LiCl according to Knochel's procedure 39 was added successfully to activated amide 4k (70% yield ...

Looking for an environmentally friendly alternative, chemists at the University of Manchester led by Jason Micklefield found that they could make amides by combining enzyme and copper catalysts ...

A pair of copper catalysts can create chiral amides in a new, light-driven process, offering a useful alternative to the standard method for making these staples of medicinal chemistry (Nature ...

Use of this paste form of Grignard reagent in subsequent reactions led to yields of up to 94% of the desired product (Photo: Koji Kubota). view more . Credit: Koji Kubota.