Noncovalent interactions define and modulate biomolecular structure, function, and dynamics. In many protein secondary structures, an intimate interaction exists between adjacent carbonyl groups of ...

In 1963, Swiss chemist Albert Hofmann discovered what gave morning glories psychoactive properties, the lysergic acid amides that would later lead him to (accidentally) create LSD. Morning glories ...

Soupçonné d’être à l’origine de plusieurs enlèvements dans le milieu des cryptomonnaies, Badiss Mohammed Amide Bajjou a été interpellé au Maroc mardi 3 juin. Voici ce que l’on sait ...

Darolutamide is the first and only in the U.S. and FDA-approved androgen receptor inhibitor (ARi) for the treatment of patients with hormone-sensitive prostate cancer (mHSPC), in combination with ...

The FDA has approved darolutamide (Nubeqa; Bayer Healthcare Pharmaceuticals) for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC), expanding its use beyond ...

In modern organic chemistry, 1,2-hydride shifts of carbocations are generally considered to be highly rapid processes, typically exhibiting activation barriers of ∼2–4 kcal/mol─significantly faster ...

Darolutamide, combined with ADT, significantly improves rPFS and OS in mCSPC patients, reducing radiological progression risk by 46%. The ARANOTE trial demonstrated clinical benefits across all ...

Na maioria dos casos as amidas graxas foram obtidas em bons rendimentos utilizando uma proporção molar de 1:6, éster graxo:amina. Entretanto, devido aos baixos rendimentos observados com o uso das ...