A doctor may consider ALS as a possible cause if a person has symptoms and physical examination findings with features of both upper and lower motor neuron disease. There is no cure for ALS ...

Mice in this line, called TAR4, develop ALS-related phenotypes, including severe motor impairment, loss of upper and lower motor neurons, and premature death. Homozygous mice (referred to as TAR4/4) ...

Generally, ALS is categorized in one of two ways: Upper motor neuron disease affects nerves in the brain, while lower motor neuron disease affects nerves coming from the spinal cord or brainstem. In ...

Onset was bulbar in 23% (n=7), limb in 77% (n=23; 10 upper limb, 13 lower ... ALS with bulbar onset, onset later in life, or in the definite El Escorial category at presentation, does not preclude a ...

sheffield.ac.uk Background New criteria for the neurophysiological diagnosis of amyotrophic lateral sclerosis/motor neuron disease ... shima criteria equate electrodiagnostic evidence of lower motor ...

Notably, in Group 2, NfL levels were significantly lower than placebo ... mechanisms of ALS by leveraging MSCs derived from the patient's own bone marrow. These cells exert anti-inflammatory and ...

Use of common psychiatric medications (anxiolytics, hypnotics and sedatives, and antidepressants) is linked to a higher risk ...

UC Irvine researchers conducted a study to better understand the molecular basis of amyotrophic lateral sclerosis (ALS), a ...

A man with a severe speech disability is able to speak expressively and sing using a brain implant that translates his neural ...