Perspective from These results highlight the role the ALK pathway plays in these rare diseases. Patients with ALK-driven anaplastic large cell lymphoma and inflammatory myofibroblastic tumors have ...

It is challenging to balance physician autonomy with rigid clinical pathways when it comes to these institutional decisions, which often are made by a small group. The management of ALK-positive ...

About 3-5 percent of those patients are thought to have ALK gene rearrangements and have been shown to respond to therapies that block the ALK pathway. The Vysis ALK Break Apart FISH probe kit ...

If validated, the use of anaplastic lymphoma kinase (ALK) inhibitors may be a new treatment ... and animal models to evaluate protein-signaling pathways and genetic abnormalities with the goal ...

REQORSA has a multimodal mechanism of action whereby it interrupts cell signaling pathways that cause replication and proliferation of cancer cells, such as the ALK pathway, re-establishes ...

The mutations led to diseased cells. Finally, the researchers tested JAK/STAT3 pathway inhibitors in mice implanted with tumors derived from patients with ALK-negative ALCL. Tumor growth was ...