Here, we discover lysophospholipids as endogenous pannexin activators, using activity-guided fractionation of mouse tissue extracts combined with untargeted metabolomics and electrophysiology. We show ...

Exicure, Inc. (Nasdaq: XCUR) today shared updates on its lead asset, GPC-100 (burixafor), a small molecule CXCR4 inhibitor. Exicure, Inc. ("Exicure") is planning for a clinical trial in Acute Myeloid ...

A large database study suggests that patients with primary dysautonomias face a significantly increased risk for seborrheic ...

At AAN 2025, three posters presented the sustained long-term efficacy and real-world impact of Lundbeck’s Vyepti for migraine ...

Agitated patients are often prescribed antipsychotic medications and sedatives off-label, but this can pose a risk to the ...

Objective: To compare the haemodynamic effects of nebivolol, a highly selective antagonist of 1-adrenergic receptors with additional actions caused via the L-arginine/nitric oxide pathway ...

Kratom comes from the leaves of Mitragyna speciosa, a tree found in Southeast Asia. For hundreds of years, people in Malaysia ...

Kratom, scientifically known as Mitragyna speciosa, has been used for centuries as a natural remedy for pain relief, energy enhancement, and relaxation. Originating from Southeast Asia, this herbal ...

The nicotinic acetylcholine receptors (nAChRs) are the most well understood membrane receptors for neurotransmitters at the structural and functional level. They are integral allosteric membrane ...

In the PNS, NO is an inhibitory neurotransmitter that mediates the non-adrenergic, non-cholinergic relaxation of smooth muscle in both the gastrointestinal and urogenital tracts. NO exerts its ...

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