The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers at UZH have now shown ...

In the present study, we tested the hypothesis that adiponectin protects against hyperpermeability of an endothelial cell monolayer induced by Ang II or TNF-α. In addition, the potential role of the ...

The purpose of this study was to investigate the protective effects of adiponectin treatment on endothelial cells and its mechanism. Male Wistar rats underwent cecal ligation and puncture (CLP) before ...

This study aimed to determine whether MG increases reactive oxygen species (ROS) and permeability by reducing tight junction proteins in human cerebral microvascular endothelial cells (hCMEC/d3), and ...

Adiponectin and CTRP9 can activate the AMPK pathway by ... Furthermore, it inhibits ROS generation in endothelial cells through cAMP/PKA-dependent signaling. PGRN directly binds to TNF receptor (TNFR) ...

Moreover, endothelial cells secrete extracellular vesicles (EVs) that target adipocytes in vivo. The endothelial EVs secretion is hampered in obesity and may be affected by the adipocyte-derived ...

Adiponectin is a peptide hormone secreted by the adipocytes. Other cells such as skeletal and cardiac myocytes as well as endothelial cells also produce adiponectin. This hormone plays a key role ...

29 Moreover, adiponectin reduces the secretion of interleukin-6 (IL-6) from brain endothelial cells in response to oxidative stress, modulating BBB function. 30 Judging from previous evidences ...

Circulating adiponectin was lower in WT-HF mice versus WT controls ... This is the first study to demonstrate that targeting endothelial cells in mice fed an HF diet with human CYP2J2 decreased ...

Cultured human umbilical vascular endothelial cells (HUVECs) and osteoblasts were stimulated with adiponectin (1 or 10 μg ml −1) or IL-1β (0.1 ng ml −1) in the presence or absence of ...

Adiponectin exerts its beneficial effects through membrane-bound receptors and adaptor molecules in endothelial cells. Adiponectin increases the stability of eNOS mRNA and half-life, enhances the ...