Second, microtubule diversity is also generated by an extensive array of reversible post-translational modifications 2, such as acetylation, polyglycylation and polyglutamylation, tyrosination ...

Phosphorylation is so far the most intensively studied post-translational modification in the autophagy process, followed by ubiquitination and acetylation.

Post-translational modifications (PTMs) are essential players in regulating protein functions, including stability, localization, and interactions, and they ...

Post-translational modifications (PTMs)—the chemical changes that proteins undergo following biosynthesis—account for most protein forms, or proteoforms. Indeed, according to conservative ...

PCAF acetylates RAD51, leading to RAD51 dissociation from chromatin and degradation. This highlights a regulatory role for ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Dr. Edward Arnold, a graduate student in the Avgousti lab, led critical studies to define the purpose of these modifications in adenoviral replication. To start, the group created adenoviruses with ...

Post-translational modifications (PTMs) provide a rapid mechanism that enables protein phenotypic diversity so that proteins can react to external and internal disturbances and regulate cellular ...

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A ...

By Vijay Kumar Malesu These modifications increase chromatin accessibility, influencing growth, differentiation, and ion ...

Proteomics of tau extracted from human brain maps tau post-translational modifications on largest scale yet. Specific changes track with tau’s aggregation propensity and disease stage. As ...